BIOL 310 - Genetic Analysis I

Units: 4
A comprehensive analysis of gene structure, function, and inheritance incorporating classical and molecular-based approaches. Emphasis on the experimental evidence that has led to our current understanding of the nature of the gene, drawing on examples from bacteria to humans. Lecture Units: 3; Activity Units: 1.

Prerequisites: BIOL 140B with a grade of C- or better.
Possible Instructional Methods: On-ground.
Grading: A-F or CR/NC (student choice).
Course Typically Offered: Fall & Spring

Student Learning Outcomes - Upon successful completion of this course students will be able to:

describe the cellular and chromosomal events that occur during normal and abnormal mitosis and meiosis;
describe Mendel’s laws of equal segregation and independent assortment and use probability (product and sum rules) and statistical tests (i.e. chi-square) to analyze phenotypic data to explain adherence to or deviation from these laws (i.e. linkage, epistasis);
define the word “gene” and explain the relationship between genotype and phenotype when considering traits influenced by alleles of one or two genes;
apply principles of heredity in the assessment of human pedigrees (i.e. identify the mode of inheritance for a given trait, and predict mating outcomes);
compare and contrast DNA and RNA at the molecular level. describe the molecular mechanism of DNA replication, proofreading and repair;
describe the molecular events associated with gene expression (transcription and/or translation) and explain how these processes can be regulated;
explain modern molecular techniques used to find genes on a chromosome and measure gene expression (among others);
access and utilize genetic information from public databases to learn about gene structure, the relationship between genotype and phenotype.